Potential Influence of Selenium, Copper, Zinc
and Cadmium on L-Thyroxine Substitution in Patients with Hashimoto
Thyroiditis and Hypothyroidism
Exp Clin Endocrinol Diabetes. 2017 Feb;125(2):79-85. doi: 10.1055/s-0042-116070. Epub 2016 Oct 28.
Rasic-Milutinovic Z, et al.
(AA) Background: Besides genetic
factors, it is known that some trace elements, as Selenium, Copper, and
Zinc are essential for thyroid gland fuction and thyroid hormone
metabolism. Moreover, there were some metals effect that suggested
patterns associated with overt thyroid disease.
Aim of study: Hashimoto
thyroiditis (HT), chronic autoimune inflamation of thyroid gland with
cosequtive hipothyroidism, is common disease in Serbia, and we thought
it is worthwile to explore potential effects of essential and toxic
metals and metalloides on thyroid function and ability to restore
euthyroid status of them.
Results: This cross-sectional,
case-control, study investigated the status of essential elements
(Selenium,Copper,and Zinc) and toxic metals and metalloides (Al, Cr, Mn,
Co, As, Cd, Sb, Ba, Be, Pb and Ni) from the blood of 22 female,
patients with Hashimoto thyroiditis and overt hypothyroidism, and
compared it with those of 55 female healthy persons. We tried to
establish the presence of any correlation between previous mentioned
elements and thyroid function in hypothyroid patients and healthy
Conclusions: The results of our
study suggested that the blood concentration of essential trace
elements, especially the ratio of Copper, and Selenium may influence
directly thyroid function in patients with HT and overt
hypothyroidism.Thus, our findings may have implication to life-long
substitution therapy in terms of l-thyroxine dose reduction.
Furthermore, for the first time, our study shown potential toxic effect
of Cadmium on thyroid function in HT patients, which may implicate the
dose of l-thyroxine substitution.
Role of Magnesium in Oxidative Stress in Individuals with Obesity
Biol Trace Elem Res. 2017 Mar;176(1):20-26. doi: 10.1007/s12011-016-0793-1. Epub 2016 Jul 22.
Morais JB, et al.
(AA) Adipose tissue is considered an
endocrine organ that promotes excessive production of reactive oxygen
species when in excess, thus contributing to lipid peroxidation.
Magnesium deficiency contributes to the development of oxidative stress
in obese individuals, as this mineral plays a role as an antioxidant,
participates as a cofactor of several enzymes, maintains cell membrane
stability and mitigates the effects of oxidative stress. The objective
of this review is to bring together updated information on the
participation of magnesium in the oxidative stress present in obesity.
We conducted a search of articles published in the PubMed, SciELO and
LILACS databases, using the keywords 'magnesium', 'oxidative stress',
'malondialdehyde', 'superoxide dismutase', 'glutathione peroxidase',
'reactive oxygen species', 'inflammation' and 'obesity'. The studies
show that obese subjects have low serum concentrations of magnesium, as
well as high concentrations of oxidative stress marker in these
individuals. Furthermore, it is evident that the adequate intake of
magnesium contributes to its appropriate homeostasis in the body. Thus,
this review of current research can help define the need for
intervention with supplementation of this mineral for the prevention and
treatment of disorders associated with this chronic disease.