Sunday, 20 October 2019

Vol. 19, No. 2 (August 2010)

Zinc and Inflammation

Zinc is a group llb metal, and is of critical importance.  It is second only to iron in worldwide incidence of defi­ciency, impacting 2 billion people in developing nations.  It plays many maintenance roles in cellular metabo­lism and gene expression.  Depending on the source, it is part of between 100 and 300 biological enzymes in the body.  The cellular processes regulated by zinc, include mitosis, apoptosis, secretion and signal transduction.  It is critical to a diverse group of physi­ological processes, such as insulin wound healing, vision, and neuro­transmission. Given the wide range of functions impacted or regulated by zinc (See Figure 1 below), it can be seen that its deficiency, or even marginal deficiency can have seri­ous health implications. In this issue, we are looking more specifically at areas in which the anti-inflammatory effect of zinc is of utmost importance. Involving things such as T Cell cytokine expression, NF kappaB signaling PPAR, COX-2 expression, and down regulation iNOS, among others. To emphasize the impact that zinc has as an anti-inflammatory activist, the following abstracts will show a variety of pathologies in which zinc can exhibit its anti-inflammatory ben­efits, including things, as diverse as anti-aging effects, asthma and other airway diseases, inflammatory acne, bronchiolar allergic inflammation, auto­immune disease, sickle cell anemia, and inflammatory diseases such as atherosclerosis.
 
The Essential Toxin: Impact of Zinc on Human Health”, Laura M. Plum, et al., Int J Environ Res Public Health 2010; 7, 1342-1365 

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